The immune system is known to react to stress by becoming suppressed. When appropriate, this suppression of the immune system is the way in which the body combats immediate danger by generating the fight or flight response for a brief moment. Even though the flight or fight response is a good thing in the short term, when it’s repeatedly triggered, however, it creates some adverse health consequences; if the state of stress is maintained for a long time the more vulnerable the body becomes for diseases to occur.  When the stress-inducing events continue and chronic stress sets in, individuals’ vulnerability and susceptibility to infections and other illnesses by reducing resistances of the immune system also increases. As stressful events continue and persist the physical damage also become severe and dangers for life. Chronic stress produces bodily consequences that can trigger physical aliments ranging from headaches, sleeplessness, to metabolic disorders, such as weight gain/lose, cancer, diabetes, hormonal imbalance, heart problems, and immune system diseases.

The effect of stress on the body is not limited to the immune system in isolation, it also involves the entire system of the neuroendocrine-immune pathways mediated by the brain through the activities of neurotransmitters and neurohormones. Stress, thus, directly and indirectly involves in the regulation of neurochemicals, which in turn affects the physical and psychological functioning of the individual and at times, groups collectively. The physiological aspect of stress is deeply connected within the neuroimmune and endocrine system. The brain reacts to the hormonal signals generated in response to stressful events and in turn produces neurochemicals, which affect the function of the entire body. Following the brains reaction to the hormonal signals, additional signals are send to shut down the functions of the internal organs and execs glucose is released and blood pressure is raising and so on. In such complex and integrated way stress, causes serious damage on the physical and mental health of people.

In other word stress involves the psychoneuroimmune system, which is a vital life- line system in the body. And when this important system is adversely affected and compromised, the integrity of the whole person that is the balance between and within the mind, body and soul functions, is as well, greatly distorted and compromised. Simply, it means that, stress becomes maladaptive and manifests itself as a host of mental and physical illnesses. It is important to note that as the disease processes associated with stress involves both physiological and psychological functioning, similarly, preventing, managing, modifying and neutralizing stressful events must involves holistic approaches, integrating body, mind and soul.